Palonosetron Hydrochloride Injection– Anti-emesis After Chemotherapy Or Radiotherapy, CAS No.: 135729-62-3, Palonosetron Hydrochloride Injection 0.25mg/5ml, 0.075mg/1.5ml

Introduction:

Palonosetron Hydrochloride Injection is a medication designed to combat nausea and vomiting in patients who undergo chemotherapy or radiotherapy. It has been developed by our company in China and is now available for wholesalers and retailers in other countries.

Our product is manufactured using high-quality processes and raw materials to ensure its efficacy and safety. The active ingredient, Palonosetron Hydrochloride, is an antiemetic agent that works by blocking serotonin receptors in the brain and gastrointestinal tract. This helps prevent the activation of the vomiting reflex and reduces the occurrence of nausea and vomiting in patients.

In this article, we will explore the various aspects of our product that make it an excellent choice for merchants looking to add a reliable, high-quality medication to their product range.

1. Clinical Efficacy:

Clinical studies have shown that Palonosetron Hydrochloride Injection is highly effective in preventing and controlling nausea and vomiting associated with chemotherapy or radiotherapy. In randomized, double-blind studies, Palonosetron was found to be superior to other antiemetic agents in preventing acute and delayed nausea and vomiting.

This makes our product an excellent choice for wholesalers and retailers looking to provide their customers with effective medication that delivers results, so they can have a positive experience during their cancer treatment.

2. Low Incidence of Side Effects:

Unlike other antiemetic agents, Palonosetron Hydrochloride Injection is associated with a low incidence of side effects. This is because it is highly selective in its action and does not affect other receptors in the body.

This means that our product can be used safely and effectively in patients who may be sensitive to other antiemetic medications, providing a safe alternative to those who need it.

3. Convenient Dosage:

Palonosetron Hydrochloride Injection comes in two different dosages: 0.25mg/5ml and 0.075mg/1.5ml. This provides healthcare providers with a convenient and flexible dosing option that can be tailored to individual patient needs.

Our product is supplied in pre-filled syringes that can be administered quickly and easily, making it an excellent choice for busy hospitals and clinics that need to treat large numbers of patients every day.

4. Long-Lasting Effect:

Palonosetron Hydrochloride Injection has a long-lasting effect, providing patients with relief from nausea and vomiting for up to five days after chemotherapy or radiotherapy. This means that patients can enjoy a better quality of life during their treatment and can recover more quickly after their therapy sessions.

This makes our product an excellent choice for wholesalers and retailers who want to provide their customers with a medication that offers long-lasting relief from the unpleasant side effects of cancer treatment.

5. Regulatory Compliance:

Our product is manufactured in compliance with the highest quality standards, ensuring that it is safe and effective for use in patients. It has been approved for use by regulatory authorities in many countries and is registered as a Class II medical device in China.

This means that wholesalers and retailers can have confidence in the quality and safety of our product, knowing that it has undergone rigorous testing and meets all necessary regulatory requirements.

Conclusion:

Palonosetron Hydrochloride Injection is an excellent choice for merchants looking to expand their product offering in the antiemetic medication market. With its proven clinical efficacy, low incidence of side effects, convenient dosage, long-lasting effect, and regulatory compliance, it is an excellent choice for hospitals, clinics, and other healthcare providers.

We encourage merchants who are interested in our product to get in touch with us to learn more and discuss how we can work together to provide patients with the best possible medication for cancer treatment.

DESCRIPTION

Palonosetron Hydrochloride Injection contains palonosetron as palonosetron HCl, an antiemetic and antinauseant agent. It is a serotonin-3 (5-HT3) receptor antagonist with a strong binding affinity for this receptor. Chemically, palonosetron HCl

is: (3aS)-2[(S)-1­ Azabicyclo [2.2.2]oct-3-yl]-2,3,3a,4,5,6-hexahydro-1-oxo-1Hbenz[de]isoquinoline hydrochloride.

The empirical formula is C19H24N2O.HCl, with a molecular weight of 332.87. Palonosetron HCl exists as a single isomer and has the following structural

formula:

Palonosetron HCl exists as a single isomer.

Palonosetron HCl is a white to off-white crystalline powder. It is freely soluble in water, soluble in propylene glycol, and slightly soluble in ethanol and 2-propanol.

Palonosetron HCl Injection is a sterile, clear, colorless, non pyrogenic, isotonic, buffered solution for intravenous administration. Palonosetron

HCl Injection is available as 5 mL single-dose vial or a 5 mL single-dose prefilled syringe. Each 5 mL vial and prefilled syringe contains: 0.25 mg palonosetron base equivalent to 0.28 mg palonosetron HCl, 40 mg sodium chloride, 18 mg trisodium citrate dihydrate, 7 mg citric acid anhydrous, and water for injection.

The pH of the solution in the 5 mL vial and prefilled syringe is 4.5 to 5.5.

Mechanism of Action

Palonosetron is a 5-HT3 receptor antagonist with a strong binding affinity for this

receptor and little or no affinity for other receptors.

Cancer chemotherapy may be associated with a high incidence of nausea and vomiting, particularly when certain agents, such as cisplatin, are used. 5-HT3 receptors are located on the nerve terminals of the vagus in the periphery and centrally in the chemoreceptor trigger zone of the area postrema. It is thought that chemotherapeutic agents produce nausea and vomiting by releasing serotonin from the enterochromaffin cells of the small intestine and that the released serotonin then activates 5HTreceptors located on vagal afferents to initiate the vomiting reflex.

Postoperative nausea and vomiting is influenced by multiple patient, surgical and

anesthesia related factors and is triggered by release of 5-HT in a cascade of neuronal

events involving both the central nervous system and the gastrointestinal tract.

The 5-HT3 receptor has been demonstrated to selectively participate in the emetic response.

Pharmacodynamics

Cardiac Electrophysiology

The effect of intravenous palonosetron on blood pressure, heart rate, and ECG parameters including QTc were comparable to intravenous ondansetron and dolasetron in CINV clinical trials. In PONV clinical trials the effect of palonosetron on the QTc interval was no different from placebo. In non-clinical studies palonosetron possesses the ability to block ion channels involved in ventricular de- and re-polarization and to prolong action potential duration. The effect of palonosetron on QTc interval was evaluated in a double blind, randomized,

parallel, placebo and positive (moxifloxacin) controlled trial in adult men and women.

The objective was to evaluate the ECG effects of intravenously administered

palonosetron HCl at single doses of 0.25, 0.75 or 2.25 mg in 221 healthy subjects.

At a dose 9 times the maximum recommended dose, palonosetron did not prolong the QT interval to any clinically relevant extent.

[Name]

Generic Name: Palonosetron Hydrochloride injection

The quality and efficacy consistency of generic drugs were evaluated.

The second generation 5-HT3 receptor antagonist, super antagonistic, long - lasting antiemetic.

The only 5-HT3 receptor antagonist FDA-approved for the prevention of delayed chemotherapy-induced nausea and vomiting.

Dosage Form: Injection

Specification: 5ml: 0.25mg, 1.5ml: 0.075mg

[Indication]

1. To prevent nausea and vomiting which are induced by tumor treatment (Radiotherapy or chemotherapy)

2. To prevent nausea and vomiting after anesthesia and surgery.

3. To prevent postoperative nausea and vomiting within 24 hours after surgery.

Hangzhou Jiuyuan is a top-biotech joint venture specializing in the research, development, manufacture, and marketing of pharmaceuticals based on gene engineering and biochemical technology since 1993. It has gene engineering workshops, injection workshops, pharmaceutical API workshops, and other sections including the quality management department, warehouse, engineering department, etc., all of which are built according to GMP requirements. Jiuyuan is equipped with advanced production and analysis instruments like chromatography systems, HPLC, and capillary electrophoresis. We offer high-quality products and comprehensive sales services, please contact us.

Company Honor

National New High-tech Enterprise

Key New High-tech Enterprise of National Torch Plan

National superior enterprise of intellectual property

Provincial New High-tech Research & Development Center

Zhejiang Provincial Enterprise Technology Center

Zhejiang Famous Trademark

Zhejiang Jiuyuan Gene Engineering Biopharmaceutical Research Institute

FAQ

Q: Are you trading company or manufacturer?

A: We are professional manufacturer specialized in the research, development, manufacture and marketing of pharmaceuticals based on gene engineering and biochemical technology since 1993.

And we trade our products with our clients directly.

Q: How many different types of products your company manufactures?

A: Now we have 36 products including pipeline products. All the pharmaceutical manufacturing activities are carried as per GMP requirements. The day to day licensing and regulatory activities are controlled by SFDA.

Q: When can I get the price?

A: Usually we quote within 8 hours after we get your inquiry.

Q: What's your MOQ?

A: If we have the products in stock, it will be no MOQ. If we need to produce, we can discuss the MOQ according to customer's exact situation.

Q: How long is your delivery time?

A: The general delivery time is 30-45 days after receiving your order confirmation. if we have the goods in stock, it will only take 1-2 days.

Q: Do you provide sample? Is it free?

A: If the sample is low value, we will provide the free sample with freight collect. But for some high value samples, we need to collect the sample charge.

Our Service

1. More Professional service in Packaging and printing products exporting field

2. Better manufacture ability

3. Various payment term to choose:T/T, Western Union, L/C, Paypal

4. High quality/ Competitive price

5. Small order available

6. Quickly response

7. More safe and fast transport

Why choose us?

• We are a Chinese factory that specializes in providing top-quality Oncology Injection products and professional services.
• Our rich industrial experience and expertise allow us to provide premium quality products with high cost performance for our customers. We are constantly adding new and innovative products to keep up with the changing demands of our customers.
• Our Chinese factory offers flexible pricing and customization options, making it easier for our customers to obtain the best shot at an affordable rate.
• We strive to achieve the enterprise super-regular leap-forward development.
• Our Chinese factory has a team of skilled professionals who are dedicated to providing timely and efficient services to our clients.
• Using high-quality raw materials is also a good way to reduce production waste and improve the output of first-class Palonosetron Hydrochloride Injection– Anti-emesis After Chemotherapy Or Radiotherapy, CAS No.: 135729-62-3, Palonosetron Hydrochloride Injection 0.25mg/5ml, 0.075mg/1.5ml.
• Our skilled research and development team has the expertise to create custom Oncology Injection products to meet specific customer requirements.
• Our company values the business philosophy of people-oriented and quality-oriented.
• We provide comprehensive packaging solutions for our Oncology Injection products, ensuring that they are protected during transportation and storage.
• We occupy the market with high quality products, and take brand expansion as our development strategy.

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