Fosaprepitant Dimeglumine Injection， CAS No.: 265121-04-8，Bulk and Injection（vial）150mg/5ml

Introduction:

Fosaprepitant Dimeglumine Injection, with the CAS No.: 265121-04-8, is a medication used in the prevention of delayed nausea and vomiting associated with chemotherapy. It is particularly effective for patients undergoing high-dose chemotherapy or targeted therapy.

As a reliable and experienced manufacturer in China, we're proud to offer this high-quality medication to merchants worldwide. Our product - Fosaprepitant Dimeglumine Injection, comes in both bulk and injection (vial) form and contains 150mg/5ml. In the following sections, we'll discuss the various aspects of our product that make it an attractive and effective choice for physicians and medical practitioners around the world.

Benefits of Fosaprepitant Dimeglumine Injection:

The benefits of Fosaprepitant Dimeglumine Injection are numerous. This medication is used to prevent delayed nausea and vomiting associated with chemotherapy in patients, particularly those undergoing high-dose chemotherapy or targeted therapy. The medication works by blocking a substance in the brain that is responsible for causing nausea and vomiting, making it an effective solution for patients who experience these side effects.

Fosaprepitant Dimeglumine Injection is also beneficial for medical professionals, as it is easy to use and can be administered in a hospital, clinic or even a patient's own home. The injection form of Fosaprepitant Dimeglumine Injection is particularly suitable for patients who are unable to take oral medication, such as those with gastrointestinal complications.

Furthermore, our product has a long shelf life, ensuring that it can be stored and used for an extended period of time. This feature makes it an excellent choice for merchants who want to stock products in their inventory that won't expire quickly.

Quality Assurance:

At our manufacturing facility, we follow a strict quality control process that ensures that all of our products are of the highest quality possible. Our testing and validation procedures are designed to identify any inefficiencies or inconsistencies in our processes, ensuring that our products are always safe and effective.

Our commitment to quality assurance extends to our product packaging, which is designed to keep our product stable and secure during transport. This means that merchants can be confident in the safety and effectiveness of our products, even if they are shipping them across long distances.

Pricing and Delivery:

We understand that pricing is an essential consideration for merchants looking to purchase products, so we're pleased to offer our Fosaprepitant Dimeglumine Injection at competitive prices. We're committed to working with our clients to provide them with the best value products on the market.

Additionally, we offer timely delivery of our products, ensuring that clients receive their orders in a timely and efficient manner. Our delivery process is designed to be reliable, secure, and fast, providing merchants with peace of mind when it comes to shipping their products.

Conclusion:

Fosaprepitant Dimeglumine Injection is a powerful medication that offers effective relief from nausea and vomiting associated with chemotherapy. As a manufacturer based in China, we are pleased to be able to offer high-quality Fosaprepitant Dimeglumine Injection to merchants worldwide in both bulk and injection (vial) form.

Our commitment to quality assurance, competitive pricing, and reliable delivery make us an excellent choice for merchants looking to purchase medication from a trusted and experienced manufacturer. Contact us today to learn more about our product and how we can work with you to meet your needs.

DESCRIPTION

EMEND (fosaprepitant) for injection is a sterile, lyophilized formulation containing fosaprepitant dimeglumine, a prodrug of aprepitant, a substance P/neurokinin-1 (NK1) receptor antagonist, an antiemetic agent, chemically described as 1-Deoxy-1-(methylamino)-D-glucitol[3-[[(2R,3S)-2-[(1R)-1-[3,5- bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2,5-dihydro-5-oxo-1H-1,2,4- triazol-1-yl]phosphonate (2:1) (salt).

Its empirical formula is C23H22F7N4O6P ⋅ 2(C7H17NO5) and its structural formula is:

Fosaprepitant dimeglumine is a white to off-white amorphous powder with a molecular weight of 1004.83. It is freely soluble in water.

Each vial of EMEND for injection for administration as an intravenous infusion contains 150 mg of fosaprepitant (equivalent to 245.3 mg of fosaprepitant dimeglumine) and the following inactive ingredients: edetate disodium (5.4 mg), polysorbate 80 (75 mg), lactose anhydrous (375 mg), sodium hydroxide and/or hydrochloric acid (for pH adjustment).

Mechanism of Action

Fosaprepitant is a prodrug of aprepitant and accordingly, its antiemetic effects are attributable to aprepitant. Aprepitant is a selective high-affinity antagonist of human substance P/neurokinin 1 (NK1) receptors. Aprepitant has little or no affinity for serotonin (5-HT3), dopamine, and corticosteroid receptors, the targets of existing therapies for chemotherapy-induced nausea and vomiting (CINV). Aprepitant has been shown in animal models to inhibit emesis induced by cytotoxic chemotherapeutic agents, such as cisplatin, via central actions. Animal and human Positron Emission Tomography (PET) studies with aprepitant have

shown that it crosses the blood brain barrier and occupies brain NK1 receptors. Animal and human studies have shown that aprepitant augments the antiemetic activity of the 5-HT3-receptor antagonist ondansetron and the corticosteroid dexamethasone and inhibits both the acute and delayed phases of cisplatin-induced emesis.

Pharmacodynamics

Cardiac Electrophysiology

In a randomized, double-blind, positive-controlled, thorough QTc study, a single 200-mg dose of fosaprepitant (approximately 1.3 times the recommended dose) had no effect on the QTc interval.

Name: Fosaprepitant dimeglumine

Fosaprepitant dimeglumine for injection is a sterile, lyophilized formulation containing fosaprepitant dimeglumine, a prodrug of aprepitant, a substance P/neurokinin-1 (NK1) receptor antagonist, an antiemetic agent, chemically described as 1-Deoxy-1-(methylamino)-D-glucitol[3-[[(2R, 3S)-2-[(1R)-1-[3, 5bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-2, 5-dihydro-5-oxo-1H-1, 2, 4triazol-1-yl]phosphonate (2:1) (salt).

Dosage: Injection

Specification

150mg/5ml

Indications

Fosaprepitant dimeglumine for injection, in combination with other antiemetic agents, is indicated in adults for the prevention of:

acute and delayed nausea and vomiting associated with initial and repeat courses of highly emetogenic cancer chemotherapy (HEC) including high-dose cisplatin.

delayed nausea and vomiting associated with initial and repeat courses of moderately emetogenic cancer chemotherapy (MEC).

Entrepreneurship Imprint

1993

On December 31, Hangzhou Jiuyuan Gene Engineering Co., Ltd. was registered and established in Hangzhou High-tech Development Zone.

Year 1996

On October 14, the company obtained the trial production number and new drug certificate of China's first rhG-CSF injection-"Jilifen", which is the third company in the world to mass-produce this drug after the United States and Japan. nation.

Year 2006

In July, the company's fourth new product, Yizhejia (Enoxaparin Sodium), was officially produced and sold. It was the first enoxaparin sodium injection in my country to be officially approved by the state.

Year 2013

In October, the company reformed its marketing system and established a development strategy of "market first, overall marketing".

Company Honor

National New High-tech Enterprise

Key New High-tech Enterprise of National Torch Plan

National superior enterprise of intellectual property

Provincial New High-tech Research & Development Center

Zhejiang Provincial Enterprise Technology Center

Zhejiang Famous Trademark

Zhejiang Jiuyuan Gene Engineering Biopharmaceutical Research Institute

FAQ

Q: How many different types of products your company manufactures?

A: Now we have 36 products including pipeline products. All the pharmaceutical manufacturing activities are carried as per GMP requirements. The day to day licensing and regulatory activities are controlled by SFDA.

Q: What is your term of payment?

A: 30% down payment before producing and 70% balance payment before shipping.

Q: Which payment form you can accept?

A: T/T, Western Union, PayPal etc. We accept any convenient and swift payment term.

Q: Which certificate do you have?

A: GMP, EUGMP and ISO14001.

Why choose us?

• Our team of professionals is committed to delivering exceptional Oncology Injection products that provide value and quality.
• Our development vision echoes the expectations of our employees and has a solid mass and social foundation.
• Your satisfaction is our priority, and we ensure that every Oncology Injection product we manufacture passes our rigorous quality control process.
• Our company has a long history and a large scale, and also has independent intellectual property rights and patents for many products.
• If you're looking for cost-effective Oncology Injection products without sacrificing quality, our Chinese factory is the right choice.
• In the development at the same time, the company does not forget to constantly summarize, constantly optimize customer service, and as always, the enthusiasm has won high praise from new and old customers.
• Our Chinese factory offers fast and efficient shipping services for our Oncology Injection products, ensuring timely and safe deliveries.
• We continue to break through processing bottlenecks and truly realize Made in China.
• Our Chinese factory is equipped with modern facilities and equipment that enable us to produce high-quality Oncology Injection products efficiently.
• We strive to achieve the leading economic scale, leading technical level and leading production quality in the Fosaprepitant Dimeglumine Injection， CAS No.: 265121-04-8，Bulk and Injection（vial）150mg/5ml industry.

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